| San Francisco | Tack | Asst | Sack | RPlay | PPlay | | ILB Adrian Kolker | 5 | 2 | 0.0 | 19 | 23 | | OLB Roderick Green | 4 | 0 | 0.0 | 22 | 21 | | S Shane Calmus | 4 | 0 | 0.0 | 19 | 22 | | Unknown | 4 | 0 | 0.0 | 8 | 5 | | DE Dwight Freeney | 3 | 2 | 1.0 | 22 | 25 | | DT Isaac Sopoaga | 3 | 1 | 1.0 | 22 | 25 | | ILB Chester Evans | 3 | 0 | 0.0 | 9 | 2 | | S Anthony Harmon | 2 | 4 | 0.0 | 19 | 23 | | DT Leo Sheldon | 2 | 2 | 0.0 | 21 | 14 | | CB Glen Strayhorn | 2 | 1 | 0.0 | 20 | 22 | | CB Jeremy LeSueur | 2 | 0 | 0.0 | 5 | 8 | | CB Brett Parrish | 2 | 0 | 0.0 | 21 | 23 | | DE Buddy Morton | 2 | 0 | 0.0 | 20 | 23 | | CB Britt Stanton | 2 | 0 | 0.0 | 12 | 18 | | WR Wesley Stone | 1 | 0 | --- | --- | --- | | DE Leonard Gardener | 1 | 0 | 0.0 | 8 | 2 | | DT C.J. Cofield | 1 | 0 | 0.0 | 7 | 4 | | S Edward Evans | 1 | 0 | 0.0 | 6 | 8 | | TE Mitch Wolf | 1 | 0 | --- | --- | --- |
| | San Diego | Tack | Asst | Sack | RPlay | PPlay | | ILB Kyle Lucas | 12 | 3 | 0.0 | 31 | 20 | | OLB Stephen Cooper | 8 | 1 | 0.0 | 36 | 20 | | DT Kenneth Lents | 5 | 2 | 0.0 | 39 | 22 | | DE Vinny Pourdanesh | 5 | 0 | 0.0 | 34 | 21 | | DE William Burnett | 4 | 2 | 1.0 | 40 | 23 | | CB Sean Parisi | 4 | 0 | 0.0 | 20 | 16 | | S Ronnie Alexander | 3 | 5 | 0.0 | 38 | 20 | | ILB Dustin Summers | 3 | 1 | 0.0 | 15 | 6 | | S Robbie Arcenaux | 3 | 1 | 0.0 | 31 | 22 | | OLB Will Blake | 2 | 1 | 0.0 | 9 | 1 | | S Mario Marshall | 2 | 0 | 0.0 | 21 | 7 | | DT Rufus Preston | 1 | 1 | 0.0 | 30 | 19 | | CB Alvin Meier | 1 | 1 | 0.0 | 25 | 15 | | CB Darren Sims | 1 | 0 | 0.0 | 10 | 5 | | DT Austin Dole | 1 | 0 | 0.0 | 10 | 4 | | CB Rico Strickland | 0 | 2 | 0.0 | 40 | 21 |
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