| Arizona Cardinals | Injury | Status | Expected Return |
| Kai Morrill | Sprained Knee | Probable | 2 Weeks |
| Monty King | Concussion | Out (in concussion protocol) | 1 Week |
| K.C. Terrell | None | 100% |
|
| Mario Knight | None | 100% |
|
| Donald Asquith | None | 100% |
|
| Atlanta Falcons | Injury | Status | Expected Return |
| Ernie Lyle | Torn Lateral Knee Ligament | Out | 9 Weeks |
| Lionel Branston | Broken Wrist | Questionable | 4 Weeks |
| Michael Cody | Sprained Knee | Questionable | 3 Weeks |
| Tanner Kennedy | Sprained Knee | Questionable | 2 Weeks |
| Albert Horn | None | 100% |
|
| Baltimore Ravens | Injury | Status | Expected Return |
| Ian Brown | Strained Hamstring | Questionable | Unknown |
| Ernie Gerhardt | ACL Damage to the Knee | Out | 11 Weeks |
| Tarik Johnston | Concussion | Out (in concussion protocol) | 4 Weeks |
| Ron Pickrell | Separated Shoulder | Out | 3 Weeks |
| Broderick Kerr | Broken Arm | Questionable | 2 Weeks |
| Landon Hickman | Broken Toe | Probable | 1 Week |
| Roderick Fazande | Bruised Sternum | Probable | 1 Week |
| Shaun Ellis | Broken Nose | Probable | 1 Week |
| Buffalo Bills | Injury | Status | Expected Return |
| Caleb Bellando | Bruised Sternum | Probable | 7 Weeks |
| DeAndre Hendree | Reconstructive Knee Surgery | Questionable | 6 Weeks |
| Caleb Santagate | Pulled Groin | Doubtful | 4 Weeks |
| Corbin Montgomery | Pulled Groin | Questionable | 2 Weeks |
| Ramon Anthony | Elbow Contusion | Probable | 1 Week |
| Devan Bish | None | 100% |
|
| Quentin Irwin | None | 100% |
|
| Chris Forbes | None | 100% |
|
| Carolina Panthers | Injury | Status | Expected Return |
| Arnie Barker | Turf Toe | Doubtful | Unknown |
| Jacob Grudich | Broken Jaw | Out | 5 Weeks |
| Donovan Zandofsky | Bruised Heel | Probable | 2 Weeks |
| Chicago Bears | Injury | Status | Expected Return |
| Sammie Lyon | Strained Hamstring | Questionable | Unknown |
| J.J. Schwartz | Separated Shoulder | Out | 3 Weeks |
| Cincinnati Bengals | Injury | Status | Expected Return |
| Andre Kiel | Knee Tendinitis | Probable | 5 Weeks |
| Fernando Meadows | Pulled Groin | Questionable | 3 Weeks |
| Brad Pritchett | Dislocated Elbow | Doubtful | 2 Weeks |
| Greg McFall | Concussion | Out (in concussion protocol) | 2 Weeks |
| Darryl Gurley | Broken Ankle | Doubtful | 2 Weeks |
| Claude Gavalas | Hyperextended Knee | Probable | 1 Week |
| Chuck Randle | Hyperextended Knee | Probable | 1 Week |
| Omar Gillespie | Hyperextended Knee | Probable | 1 Week |
| Spencer Lighthiser | Sprained Ankle | Probable | 1 Week |
| Cleveland Browns | Injury | Status | Expected Return |
| Erick Stamm | High Ankle Sprain | Out | 8 Weeks |
| Ian Brian | Concussion | Out (in concussion protocol) | 7 Weeks |
| Jerry Godinez | Hyperextended Knee | Questionable | 2 Weeks |
| Riddick Lane | Broken Foot | Probable | 1 Week |
| Floyd Fletcher | None | 100% |
|
| Lorenzo Newman | None | 100% |
|
| Dallas Cowboys | Injury | Status | Expected Return |
| Erick Humes | ACL Knee Surgery | Out | 53 Weeks |
| Vinny Orbik | Separated Shoulder | Out | 2 Weeks |
| Kyle Moln | Strained Elbow Tendon | Probable | 1 Week |
| Denver Broncos | Injury | Status | Expected Return |
| Andrew Carlisle | Severe Depression | Out | Unknown |
| Nate Granados | Severe Hamstring Pull | Out | 16 Weeks |
| Joey Mazurek | Concussion | Out (in concussion protocol) | 2 Weeks |
| Ty Nicoloro | Sprained Knee | Probable | 2 Weeks |
| Nicholas Petitgout | Sprained Knee | Questionable | 2 Weeks |
| Gustavo Wonders | Bruised Heel | Probable | 2 Weeks |
| Nolan Lester | Sprained Knee | Probable | 1 Week |
| Bradley Gonzales | None | 100% |
|
| Detroit Lions | Injury | Status | Expected Return |
| Earnest Capatina | Ruptured Elbow Tendon | Probable | 5 Weeks |
| Christian Kemp | Concussion | Out (in concussion protocol) | 4 Weeks |
| Danny Patterson | Broken Toe | Questionable | 3 Weeks |
| Bert Hanshew | Concussion | Out (in concussion protocol) | 3 Weeks |
| Irv King | Sprained Ankle | Probable | 2 Weeks |
| Sammie Trent | Broken Toe | Probable | 2 Weeks |
| Philip Battle | Knee Tendinitis | Probable | 1 Week |
| Rusty McDowell | Bruised Ribcage | Probable | 1 Week |
| Green Bay Packers | Injury | Status | Expected Return |
| Russell Jordan | MCL Knee Surgery | Out | 29 Weeks |
| Mitchell Baskerville | Severe Hamstring Pull | Out | 11 Weeks |
| Byron Schulz | Concussion | Out (in concussion protocol) | 8 Weeks |
| Ross Wagner | Broken Wrist | Out | 6 Weeks |
| Mitchell DeJesus | Separated Shoulder | Out | 5 Weeks |
| Gabriel Wiggins | None | 100% |
|
| Austin Parker | None | 100% |
|
| Houston Texans | Injury | Status | Expected Return |
| Phil Baker | MCL Damage to the Knee | Out | 5 Weeks |
| Brendan Stevenson | Knee Bursitis | Probable | 2 Weeks |
| Don Stevens | Broken Foot | Probable | 2 Weeks |
| Kurt Fitzgerald | Sprained Ankle | Probable | 2 Weeks |
| Eddie Berner | Pulled Groin | Probable | 1 Week |
| Micah Bernard | None | 100% |
|
| Indianapolis Colts | Injury | Status | Expected Return |
| Kody Freeman | Turf Toe | Doubtful | Unknown |
| Harris Richmond | Broken Clavicle | Out | 6 Weeks |
| Ted Perry | Hyperextended Knee | Questionable | 2 Weeks |
| Craig Simmons | Sprained Ankle | Probable | 1 Week |
| Wade Barber | Bad Cold | Probable | 1 Week |
| Kelly Grisham | None | 100% |
|
| Jacksonville Jaguars | Injury | Status | Expected Return |
| Earnest Shea | Turf Toe | Doubtful | Unknown |
| Marco Chapman | Broken Foot | Out | 8 Weeks |
| Mitchell Fitzgerald | Knee Tendinitis | Probable | 4 Weeks |
| Alejandro Kulaga | Sprained Thumb | Probable | 2 Weeks |
| Buddy Watson | Broken Wrist | Probable | 2 Weeks |
| Wes Yaros | Sprained Ankle | Probable | 1 Week |
| Kansas City Chiefs | Injury | Status | Expected Return |
| Josiah Bush | ACL Knee Surgery | Out | 37 Weeks |
| Malachi Van Meter | Torn Wrist Tendon | Out | 4 Weeks |
| Gregory Eppright | Sprained Knee | Questionable | 3 Weeks |
| Braden Bethel | Concussion | Out (in concussion protocol) | 2 Weeks |
| Arnie Rogers | Deep Thigh Bruise | Probable | 1 Week |
| Brody Hirshberg | Separated Shoulder | Probable | 1 Week |
| Leonardo Skelly | None | 100% |
|
| Los Angeles Rams | Injury | Status | Expected Return |
| Willie Garrett | Hyperextended Knee | Out | 4 Weeks |
| Skip Bradley | Strained Adductor Muscle | Probable | 2 Weeks |
| Spencer Spezzano | Sprained Knee | Probable | 2 Weeks |
| Clayton Nakis | Bruised Ribcage | Probable | 1 Week |
| Wesley Ramirez | Hyperextended Knee | Probable | 1 Week |
| Carl McGraw | Deep Thigh Bruise | Probable | 1 Week |
| Douglas Garrison | None | 100% |
|
| Nick Collette | None | 100% |
|
| Miami Dolphins | Injury | Status | Expected Return |
| Howie Starks | Knee Tendinitis | Probable | 4 Weeks |
| Amari Lindsay | Hyperextended Elbow | Out | 3 Weeks |
| Kaden West | Sprained Lateral Knee Ligament | Probable | 1 Week |
| Wes Leisure | None | 100% |
|
| Braxton Grant | None | 100% |
|
| Edwin Fletcher | None | 100% |
|
| Minnesota Vikings | Injury | Status | Expected Return |
| Johnathan Shello | Strained Hamstring | Questionable | Unknown |
| Randal Fritz | Concussion | Out (in concussion protocol) | 6 Weeks |
| Craig Legette | Separated Shoulder | Out | 3 Weeks |
| Lincoln Tyree | Strained Calf Muscle | Probable | 1 Week |
| Colton Sawyer | None | 100% |
|
| Colin Briggs | None | 100% |
|
| New England Patriots | Injury | Status | Expected Return |
| Dan O'Donnell | ACL Damage to the Knee | Out | 24 Weeks |
| Dexter Alexander | Torn Rotator Cuff | Out | 18 Weeks |
| Kai Burroughs | Back Surgery | Out | 17 Weeks |
| Moe Simonson | Stress Fracture in the Leg | Out | 6 Weeks |
| Ken Hoover | Pulled Calf Muscle | Out | 3 Weeks |
| Fernando Mitchell | Strained Triceps Muscle | Probable | 2 Weeks |
| Erick Monroe | Strained Foot Ligament | Probable | 2 Weeks |
| Edward Ellis | Bad Cold | Probable | 1 Week |
| Alfred Castroll | None | 100% |
|
| New Jersey Jets | Injury | Status | Expected Return |
| Van Walton | Sprained Knee | Questionable | 4 Weeks |
| Robbie Maloney | Strained Elbow Tendon | Out | 4 Weeks |
| Joel Durden | Knee Tendinitis | Probable | 3 Weeks |
| Darrell Fitzgerald | Strained Adductor Muscle | Out | 2 Weeks |
| Jamal Ramsey | Knee Tendinitis | Probable | 2 Weeks |
| Rich Raymond | Strained Achilles Tendon | Probable | 1 Week |
| New Orleans Saints | Injury | Status | Expected Return |
| Braxton Wynn | Concussion | Out (in concussion protocol) | 2 Weeks |
| Jeff McClintock | Sprained Ankle | Probable | 1 Week |
| Josh Hodges | Broken Nose | Probable | 1 Week |
| Kelly Hawkins | Pulled Calf Muscle | Questionable | 1 Week |
| Bryson Tucker | Compound Leg Fracture | Probable | 1 Week |
| Richard Dixon | None | 100% |
|
| New York Giants | Injury | Status | Expected Return |
| Malcolm Parrish | Concussion | Out (in concussion protocol) | 4 Weeks |
| Kelly Hodges | Shin Splints | Questionable | 2 Weeks |
| Braxton Jacobs | Strained Deltoid Muscle | Probable | 1 Week |
| Tanner Whiting | None | 100% |
|
| Bill Preston | None | 100% |
|
| Oakland Raiders | Injury | Status | Expected Return |
| Fred Sims | Turf Toe | Doubtful | Unknown |
| Drake Kudlacz | Repetitive Concussion Syndrome | Out | 98 Weeks |
| Levi Patterson | Torn Knee Cartilage | Out | 5 Weeks |
| Kerry Farr | Separated Shoulder | Out | 4 Weeks |
| Chance Glover | Abdominal Strain | Doubtful | 3 Weeks |
| Grant Kirchhof | Sprained Thumb | Probable | 2 Weeks |
| Bob Brady | Elbow Bursitis | Probable | 1 Week |
| Vinny Merriday | Bruised Ribcage | Probable | 1 Week |
| Mo Reed | None | 100% |
|
| Bucky Wilson | None | 100% |
|
| Eric Powell | None | 100% |
|
| Luther Sharpe | None | 100% |
|
| Philadelphia Eagles | Injury | Status | Expected Return |
| Thurman Gryboski | Concussion | Out (in concussion protocol) | 8 Weeks |
| Justics Hunter | Concussion | Out (in concussion protocol) | 5 Weeks |
| Buddy Puente | Bruised Ribcage | Probable | 3 Weeks |
| Todd Hernandez | Broken Hand | Probable | 2 Weeks |
| Marvin Arredondo | Sprained Ankle | Probable | 1 Week |
| Josh Bush | None | 100% |
|
| Pittsburgh Steelers | Injury | Status | Expected Return |
| Joey Robbins | Broken Fibula | Out | 5 Weeks |
| Seth Thibodeau | Strained Foot Ligament | Out | 3 Weeks |
| Lamont Hemphill | Sprained Thumb | Probable | 1 Week |
| Henry West | Bruised Ribcage | Probable | 1 Week |
| Jake Cortez | Pulled Calf Muscle | Questionable | 1 Week |
| San Diego Chargers | Injury | Status | Expected Return |
| David Logan | Severe Depression | Out | Unknown |
| Asher Perez | Compound Leg Fracture | Out | 36 Weeks |
| Nicholas Van Pelt | Broken Foot | Out | 9 Weeks |
| Seth Sisco | Bruised Ribcage | Probable | 3 Weeks |
| Darren Fields | Knee Tendinitis | Probable | 3 Weeks |
| Gustavo Newhart | Strained Quadriceps Muscle | Probable | 2 Weeks |
| Fred Roscoe | Bad Cold | Probable | 1 Week |
| Gino Amos | Broken Nose | Probable | 1 Week |
| Alejandro Crawford | None | 100% |
|
| Thurman Jolley | None | 100% |
|
| San Francisco 49ers | Injury | Status | Expected Return |
| Avery Schindler | Turf Toe | Doubtful | Unknown |
| Billy Gill | ACL Knee Surgery | Out | 16 Weeks |
| Ronald Joyner | Broken Clavicle | Out | 5 Weeks |
| Everett Reese | Sprained Knee | Questionable | 4 Weeks |
| Harry Phillips | Sprained Knee | Questionable | 3 Weeks |
| Lewis Hines | Bad Cold | Probable | 1 Week |
| Bernie Bridges | None | 100% |
|
| Seattle Seahawks | Injury | Status | Expected Return |
| Rickey Shaw | Strained Rotator Cuff | Probable | 4 Weeks |
| Bryan Wickland | Abdominal Strain | Doubtful | 3 Weeks |
| Scottie Humble | Concussion | Out (in concussion protocol) | 2 Weeks |
| Kendall White | None | 100% |
|
| Tampa Bay Buccaneers | Injury | Status | Expected Return |
| Micah Paige | ACL Damage to the Knee | Out | 29 Weeks |
| Chad McConnell | Broken Fibula | Out | 4 Weeks |
| Bruce Halela | None | 100% |
|
| Abel Dunphy | None | 100% |
|
| Daniel Weber | None | 100% |
|
| Tennessee Titans | Injury | Status | Expected Return |
| Irving Tucker | Torn Rotator Cuff | Out | 12 Weeks |
| Ramon Ripken | Sprained Neck | Probable | 3 Weeks |
| Dylan O'Neill | Torn Knee Cartilage | Questionable | 2 Weeks |
| Lewis Grier | Sprained Ankle | Probable | 1 Week |
| Ernie Hatton | None | 100% |
|
| Washington Commanders | Injury | Status | Expected Return |
| Winston Edwards | Separated Shoulder | Out | 5 Weeks |
| Terrence Stephens | Strained Rotator Cuff | Probable | 3 Weeks |
| Arnold Dugger | Sprained Thumb | Probable | 3 Weeks |
| Darien Simonson | Hyperextended Knee | Questionable | 2 Weeks |
| Mackenzie Lynch | Sprained Knee | Questionable | 2 Weeks |
| Wayne Sampson | Severe Wrist Sprain | Doubtful | 2 Weeks |
| Daryl Cleeland | Deep Thigh Bruise | Probable | 1 Week |