| Arizona Cardinals | Injury | Status | Expected Return |
| Derek Johnston | ACL Damage to the Knee | Out | 18 Weeks |
| Mel Konkler | Strained Patellar Tendon | Out | 5 Weeks |
| Scott Lucas | Bruised Sternum | Probable | 1 Week |
| Lenny Flynn | None | 100% |
|
| Ross Riddock | None | 100% |
|
| Atlanta Falcons | Injury | Status | Expected Return |
| Miles Desmond | Strained Hamstring | Questionable | Unknown |
| Billy Humphries | Strained Adductor Muscle | Out | 6 Weeks |
| Joey Mazurek | Knee Tendinitis | Probable | 4 Weeks |
| Nathaniel Cantu | Separated Shoulder | Out | 4 Weeks |
| Ed Nyren | None | 100% |
|
| Baltimore Ravens | Injury | Status | Expected Return |
| Britt Legins | Severe Hamstring Pull | Out | 17 Weeks |
| Fred Lugar | Sprained Knee | Questionable | 3 Weeks |
| Mitchell Berry | Deep Thigh Bruise | Probable | 2 Weeks |
| Ian Brown | Knee Contusion | Probable | 1 Week |
| Floyd Wagner | Broken Finger | Probable | 1 Week |
| K.C. Long | None | 100% |
|
| Buffalo Bills | Injury | Status | Expected Return |
| Allen Flowers | Hyperextended Knee | Out | 3 Weeks |
| Caleb Bellando | Concussion | Out (in concussion protocol) | 3 Weeks |
| Robbie Dillon | Stress Fracture in the Foot | Probable | 1 Week |
| Paul Zellerkraut | None | 100% |
|
| Carolina Panthers | Injury | Status | Expected Return |
| Adam Weber | Concussion | Out (in concussion protocol) | 7 Weeks |
| Charlie McBrayer | Concussion | Out (in concussion protocol) | 6 Weeks |
| Willie Donald | Broken Foot | Out | 5 Weeks |
| Tevin Rasnic | Torn Knee Cartilage | Out | 5 Weeks |
| Jonah Hruby | Sprained Knee | Questionable | 3 Weeks |
| Mark Horoszowski | Bruised Sternum | Probable | 2 Weeks |
| Cole Jacomy | Broken Ankle | Questionable | 2 Weeks |
| Johnny Steen | Knee Contusion | Probable | 1 Week |
| Toby Arnold | Reconstructive Knee Surgery | Probable | 1 Week |
| Moe Siglar | Strained Adductor Muscle | Probable | 1 Week |
| Abraham Clark | Sprained Ankle | Probable | 1 Week |
| Kirk Bunning | None | 100% |
|
| Leonard Vajda | None | 100% |
|
| Mickey Finley | None | 100% |
|
| Chicago Bears | Injury | Status | Expected Return |
| Skip Malone | Broken Ankle | Out | 3 Weeks |
| Cameron Nichols | Sprained Thumb | Probable | 3 Weeks |
| Howard McTyer | Strained Rotator Cuff | Probable | 1 Week |
| Sebastian Sanderson | Strained Achilles Tendon | Out | 1 Week |
| Cincinnati Bengals | Injury | Status | Expected Return |
| Darren Carey | Concussion | Out (in concussion protocol) | 7 Weeks |
| Aidan Kruger | Separated Shoulder | Out | 3 Weeks |
| Kurt Bush | Abdominal Strain | Doubtful | 3 Weeks |
| Stephen Irwin | Strained Deltoid Muscle | Out | 2 Weeks |
| Brayden Purslow | Broken Nose | Probable | 2 Weeks |
| Ezekiel Jefferson | Strained Deltoid Muscle | Out | 2 Weeks |
| Wes Berkhofer | Sprained Ankle | Probable | 1 Week |
| Brad Pritchett | None | 100% |
|
| Casey McDaniel | None | 100% |
|
| Jamie Link | None | 100% |
|
| Martin Curtis | None | 100% |
|
| Cleveland Browns | Injury | Status | Expected Return |
| Roberto Mitchell | ACL Damage to the Knee | Out | 19 Weeks |
| Benjamin Eickholt | ACL Knee Surgery | Out | 13 Weeks |
| Lorenzo Newman | Dislocated Shoulder | Out | 9 Weeks |
| Wesley Lane | Concussion | Out (in concussion protocol) | 4 Weeks |
| Riddick Lane | Broken Toe | Questionable | 3 Weeks |
| Caiden Thomas | Concussion | Out (in concussion protocol) | 2 Weeks |
| Gage Snyder | Pulled Calf Muscle | Out | 2 Weeks |
| Tucker Lysne | Hyperextended Knee | Doubtful | 2 Weeks |
| David Kieffer | Concussion | Out (in concussion protocol) | 1 Week |
| Dennis Chambliss | Hyperextended Knee | Probable | 1 Week |
| Claude Carver | None | 100% |
|
| Amari Turner | None | 100% |
|
| Kennedy McWilliams | None | 100% |
|
| Dallas Cowboys | Injury | Status | Expected Return |
| Brandon Dodge | Concussion | Out (in concussion protocol) | 8 Weeks |
| Jamal Logan | Sprained Neck | Probable | 3 Weeks |
| Ashton Wilson | Separated Shoulder | Questionable | 3 Weeks |
| Richie Elliott | Strained Foot Ligament | Probable | 1 Week |
| Deron Smithson | None | 100% |
|
| Christian Thomas | None | 100% |
|
| Terry Marshall | None | 100% |
|
| Denver Broncos | Injury | Status | Expected Return |
| Everett Forbes | Turf Toe | Doubtful | Unknown |
| Rickey Solley | Concussion | Out (in concussion protocol) | 7 Weeks |
| Henry Zellner | Broken Tibia | Out | 6 Weeks |
| Trent Stephenson | Knee Tendinitis | Probable | 5 Weeks |
| Henry Whalen | Pulled Calf Muscle | Out | 4 Weeks |
| Aidan Glover | Strained Foot Ligament | Out | 2 Weeks |
| Nate Granados | Broken Foot | Probable | 1 Week |
| Terrance Jasso | Broken Hand | Probable | 1 Week |
| Kenneth Justice | None | 100% |
|
| Ty Nicoloro | None | 100% |
|
| Rusty Godlewski | None | 100% |
|
| Detroit Lions | Injury | Status | Expected Return |
| Richard Clark | Back Surgery | Out | 17 Weeks |
| Frankie Benveniste | Strained Foot Ligament | Out | 3 Weeks |
| Earnest Capatina | Bad Cold | Probable | 1 Week |
| J.J. Fehrman | Broken Hand | Probable | 1 Week |
| Broderick Bates | Knee Tendinitis | Probable | 1 Week |
| Christian Kemp | None | 100% |
|
| Tracy Richardson | None | 100% |
|
| Green Bay Packers | Injury | Status | Expected Return |
| Hayden Conley | Repetitive Concussion Syndrome | Out | 108 Weeks |
| Marcus Crawford | Broken Clavicle | Out | 7 Weeks |
| Carson Dragonajtys | Broken Ankle | Questionable | 2 Weeks |
| Dylan Delhomme | Broken Tibia | Probable | 1 Week |
| Josiah Meggett | Bruised Heel | Questionable | 1 Week |
| Houston Texans | Injury | Status | Expected Return |
| Chandler Pratt | Back Surgery | Out | 21 Weeks |
| Chester Hopper | Abdominal Strain | Doubtful | 3 Weeks |
| Dean Cochrane | Strained Triceps Muscle | Probable | 2 Weeks |
| Gage Bennett | Elbow Contusion | Probable | 2 Weeks |
| Aaron Blackwell | Deep Thigh Bruise | Probable | 1 Week |
| Floyd Phillips | Strained Rotator Cuff | Probable | 1 Week |
| Leonard Strader | Viral Infection | Probable | 1 Week |
| Indianapolis Colts | Injury | Status | Expected Return |
| Wade Barber | Turf Toe | Doubtful | Unknown |
| Victor Godfrey | Torn Ankle Ligament | Out | 22 Weeks |
| J.R. Binkow | Ruptured Elbow Tendon | Questionable | 7 Weeks |
| Dean Vilimek | Sprained Knee | Questionable | 2 Weeks |
| Ivan Robertson | Sprained Knee | Questionable | 2 Weeks |
| Douglas Garcia | Broken Clavicle | Probable | 1 Week |
| Jacksonville Jaguars | Injury | Status | Expected Return |
| Derrick Leisure | Hyperextended Knee | Out | 4 Weeks |
| Tracy Bedwell | Broken Ankle | Out | 3 Weeks |
| Casey Schulz | Knee Tendinitis | Probable | 2 Weeks |
| Theodore McDonald | Strained Foot Ligament | Probable | 2 Weeks |
| Jared Neitring | Strained Quadriceps Muscle | Probable | 1 Week |
| Mickey Compton | Pulled Groin | Probable | 1 Week |
| Alejandro Kulaga | None | 100% |
|
| Samuel Boettcher | None | 100% |
|
| Liam Kennedy | None | 100% |
|
| Billy Austin | None | 100% |
|
| Kansas City Chiefs | Injury | Status | Expected Return |
| Colin Armistead | Bruised Sternum | Probable | 4 Weeks |
| Brody Hirshberg | Broken Tibia | Out | 4 Weeks |
| Rusty Carr | Knee Tendinitis | Probable | 1 Week |
| Donny Roberts | Bruised Sternum | Probable | 1 Week |
| Ruben Stokes | Broken Toe | Probable | 1 Week |
| Los Angeles Rams | Injury | Status | Expected Return |
| Vinny Jacquet | Inguinal Hernia | Out | 25 Weeks |
| Wally McCormick | Sprained Thumb | Probable | 4 Weeks |
| Aidan Agin | Bruised Sternum | Probable | 3 Weeks |
| Bernie Leeper | Bruised Sternum | Probable | 2 Weeks |
| Clayton Nakis | Broken Toe | Probable | 2 Weeks |
| Michael Turnbull | Broken Wrist | Probable | 2 Weeks |
| Tony Suzaka | MCL Damage to the Knee | Doubtful | 1 Week |
| Abel Lewis | Viral Infection | Probable | 1 Week |
| Jeffery Ellison | Bruised Shoulder | Probable | 1 Week |
| Courtney Navarro | None | 100% |
|
| Miami Dolphins | Injury | Status | Expected Return |
| Leon Bandhauer | Sprained Knee | Questionable | 3 Weeks |
| Ramon Mathews | Pulled Groin | Questionable | 2 Weeks |
| Kaden West | Sprained Neck | Probable | 1 Week |
| Edwin Fletcher | None | 100% |
|
| Minnesota Vikings | Injury | Status | Expected Return |
| Mario Horton | ACL Damage to the Knee | Out | 23 Weeks |
| Myles Small | Sprained Knee | Questionable | 4 Weeks |
| Robert Rodgers | Bruised Sternum | Probable | 3 Weeks |
| Glenn Fackleman | Strained Patellar Tendon | Questionable | 2 Weeks |
| Erik Lake | Broken Tibia | Questionable | 2 Weeks |
| Jeffery Cash | Abdominal Strain | Probable | 1 Week |
| New England Patriots | Injury | Status | Expected Return |
| Axel Melino | ACL Knee Surgery | Out | 51 Weeks |
| Micah Mang | Torn Quadriceps Muscle | Probable | 4 Weeks |
| Richard Rochon | Bruised Sternum | Probable | 3 Weeks |
| Joey Stuvaints | Bruised Ribcage | Probable | 2 Weeks |
| Ruben Patton | Tonsilitis | Out | 2 Weeks |
| Alfred Castroll | Separated Shoulder | Probable | 1 Week |
| Garrett Irwin | None | 100% |
|
| New Jersey Jets | Injury | Status | Expected Return |
| Jamal Ramsey | Broken Arm | Out | 5 Weeks |
| Ronald Williams | Strained Achilles Tendon | Out | 3 Weeks |
| Horace Hinsley | Separated Shoulder | Probable | 1 Week |
| Oliver Hancock | Bruised Shoulder | Probable | 1 Week |
| Nicky Horner | Broken Finger | Probable | 1 Week |
| New Orleans Saints | Injury | Status | Expected Return |
| Marcos Quinn | Ankle Surgery | Out | 26 Weeks |
| J.J. Mathai | Severe Hamstring Pull | Doubtful | 3 Weeks |
| Jesse Heath | Abdominal Strain | Doubtful | 2 Weeks |
| Theodore Maese | Strained Triceps Muscle | Probable | 1 Week |
| Gene Godfrey | None | 100% |
|
| New York Giants | Injury | Status | Expected Return |
| Ezra Fisher | Torn Rotator Cuff | Out | 17 Weeks |
| Rod Guthrie | Concussion | Out (in concussion protocol) | 9 Weeks |
| Troy Garcia | Sprained Lateral Knee Ligament | Questionable | 8 Weeks |
| Mason Pelshak | Sprained Thumb | Probable | 1 Week |
| Donnie Straight | Strained Rotator Cuff | Probable | 1 Week |
| Trenton Orton | None | 100% |
|
| Kelly Hodges | None | 100% |
|
| Oakland Raiders | Injury | Status | Expected Return |
| Sergio Einertson | Compound Leg Fracture | Out | 45 Weeks |
| Ricardo Hempstead | ACL Knee Surgery | Out | 36 Weeks |
| Ross Martino | Concussion | Out (in concussion protocol) | 4 Weeks |
| David Burke | Pulled Groin | Doubtful | 4 Weeks |
| Craig Simmons | Elbow Bursitis | Questionable | 3 Weeks |
| Levi Patterson | Broken Finger | Probable | 2 Weeks |
| Duane Strickland | Strained Patellar Tendon | Questionable | 2 Weeks |
| Cesar Cote | Sprained Ankle | Probable | 1 Week |
| Lee Acker | Torn Calf Muscle | Probable | 1 Week |
| Fred Sims | Sprained Ankle | Probable | 1 Week |
| Alejandro Burroughs | None | 100% |
|
| Drew Suckle | None | 100% |
|
| Philadelphia Eagles | Injury | Status | Expected Return |
| Alex Keith | Severe Depression | Out | Unknown |
| Jon Meadows | Compound Leg Fracture | Out | 34 Weeks |
| Myles Sutter | Broken Fibula | Out | 6 Weeks |
| Buddy Puente | Broken Nose | Probable | 1 Week |
| Cristian Henry | Bad Cold | Probable | 1 Week |
| Justics Hunter | Broken Toe | Probable | 1 Week |
| Ramon Anthony | None | 100% |
|
| Pittsburgh Steelers | Injury | Status | Expected Return |
| Joey Robbins | Concussion | Out (in concussion protocol) | 11 Weeks |
| Maurice Mathews | Knee Tendinitis | Probable | 4 Weeks |
| Conrad Copeland | Separated Shoulder | Questionable | 2 Weeks |
| Lamont Hemphill | None | 100% |
|
| San Diego Chargers | Injury | Status | Expected Return |
| Darren Fields | Torn Ankle Ligament | Out | 21 Weeks |
| Abel Jarvis | High Ankle Sprain | Questionable | 6 Weeks |
| Kai Harden | Strained Rotator Cuff | Probable | 3 Weeks |
| Ellis Bravata | Strained Elbow Tendon | Probable | 3 Weeks |
| Jermaine Bush | Ruptured Elbow Tendon | Probable | 2 Weeks |
| Louis Gardner | Deep Thigh Bruise | Probable | 2 Weeks |
| Fred Roscoe | Sprained Ankle | Probable | 1 Week |
| Russell Picchietti | Bruised Ribcage | Probable | 1 Week |
| Bradley Hill | None | 100% |
|
| Alec Beyt | None | 100% |
|
| Lamar Butler | None | 100% |
|
| San Francisco 49ers | Injury | Status | Expected Return |
| Alfred Jenkins | Degenerative Hip Condition | Out | 42 Weeks |
| Lance Whitt | Broken Tibia | Out | 9 Weeks |
| Christian Harper | Concussion | Out (in concussion protocol) | 9 Weeks |
| Grayson Collins | Hyperextended Knee | Doubtful | 3 Weeks |
| Frank Malone | Broken Hand | Probable | 2 Weeks |
| Malik Mosser | Sprained Ankle | Probable | 1 Week |
| Brock Lucas | Pulled Groin | Probable | 1 Week |
| Martin Lyle | Knee Tendinitis | Probable | 1 Week |
| Alex Hutton | None | 100% |
|
| Seattle Seahawks | Injury | Status | Expected Return |
| Philip Jacobs | ACL Knee Surgery | Out | 21 Weeks |
| Samuel Milburn | Concussion | Out (in concussion protocol) | 3 Weeks |
| Avery Wiley | Broken Toe | Questionable | 3 Weeks |
| Jeremy Nixon | Pulled Groin | Questionable | 2 Weeks |
| Fred Horowitz | Broken Finger | Probable | 2 Weeks |
| Ashton McCormick | None | 100% |
|
| Tampa Bay Buccaneers | Injury | Status | Expected Return |
| Harris Goings | Degenerative Hip Condition | Out | 73 Weeks |
| Abel Dunphy | MCL Damage to the Knee | Out | 7 Weeks |
| Todd Shepherd | Strained Foot Ligament | Out | 2 Weeks |
| Tennessee Titans | Injury | Status | Expected Return |
| Bert Blair | Broken Wrist | Probable | 1 Week |
| Kelly Spencer | Strained Rotator Cuff | Probable | 1 Week |
| Lewis Grier | Bruised Ribcage | Probable | 1 Week |
| Dean Hjelmar | None | 100% |
|
| Washington Commanders | Injury | Status | Expected Return |
| Mackenzie Lynch | Shoulder Tendinitis | Probable | 4 Weeks |
| Winston Edwards | Hyperextended Knee | Doubtful | 3 Weeks |
| Cedric Keith | MCL Damage to the Knee | Out | 3 Weeks |
| Brody Forbes | Sprained Knee | Questionable | 2 Weeks |