| Arizona Cardinals | Injury | Status | Expected Return |
| Bryant Horner | Strained Hamstring | Questionable | Unknown |
| Isaiah Hutton | MCL Damage to the Knee | Out | 7 Weeks |
| Abel Lewis | Broken Arm | Out | 6 Weeks |
| Ross Martino | None | 100% |
|
| Trent Stephens | None | 100% |
|
| Keith Sprinkle | None | 100% |
|
| Atlanta Falcons | Injury | Status | Expected Return |
| Mason Klaff | Dislocated Shoulder | Out | 6 Weeks |
| Grant Washington | Broken Ankle | Out | 6 Weeks |
| Charles McGill | Concussion | Out (in concussion protocol) | 4 Weeks |
| Ernie Lyle | Torn Lateral Knee Ligament | Questionable | 3 Weeks |
| Lionel Branston | Strained Patellar Tendon | Questionable | 2 Weeks |
| Zach Sanford | Shin Splints | Probable | 1 Week |
| Dale Henson | None | 100% |
|
| Tyrone Greene | None | 100% |
|
| Bennett Hammons | None | 100% |
|
| Baltimore Ravens | Injury | Status | Expected Return |
| Jaylen Mayes | Strained Hamstring | Questionable | Unknown |
| Ernie Gerhardt | ACL Damage to the Knee | Out | 6 Weeks |
| Stan Rydzak | Hyperextended Knee | Questionable | 2 Weeks |
| Russell Picchietti | Concussion | Out (in concussion protocol) | 2 Weeks |
| Herb Sanderson | Abdominal Strain | Questionable | 2 Weeks |
| Dusty Boehner | None | 100% |
|
| Buffalo Bills | Injury | Status | Expected Return |
| Devin Liles | Turf Toe | Doubtful | Unknown |
| Brayden Rzentkowski | Torn Knee Cartilage | Out | 5 Weeks |
| Matt King | Sprained Thumb | Questionable | 4 Weeks |
| Nick Hartwig | Hyperextended Knee | Doubtful | 3 Weeks |
| Tanner Lewis | Strained Elbow Tendon | Out | 3 Weeks |
| Caleb Bellando | Bruised Sternum | Probable | 1 Week |
| Carolina Panthers | Injury | Status | Expected Return |
| Arnie Barker | Turf Toe | Doubtful | Unknown |
| Toby Arnold | Reconstructive Knee Surgery | Out | 43 Weeks |
| Moe Siglar | ACL Damage to the Knee | Out | 16 Weeks |
| Johnnie Lampkin | Torn Thumb Ligament | Probable | 2 Weeks |
| Mark Horoszowski | Separated Shoulder | Probable | 1 Week |
| Chicago Bears | Injury | Status | Expected Return |
| Sebastian Goodwin | Sprained Neck | Probable | 2 Weeks |
| Skip Malone | Hyperextended Knee | Probable | 1 Week |
| Cincinnati Bengals | Injury | Status | Expected Return |
| Christopher Parker | Elbow Bursitis | Probable | 3 Weeks |
| Leon Thurman | Hyperextended Elbow | Out | 3 Weeks |
| Buddy Stamps | None | 100% |
|
| Brayden Purslow | None | 100% |
|
| Wes Berkhofer | None | 100% |
|
| Gordon Metz | None | 100% |
|
| Cleveland Browns | Injury | Status | Expected Return |
| Randal Woodson | Strained Hamstring | Questionable | Unknown |
| Benjamin Eickholt | ACL Knee Surgery | Out | 57 Weeks |
| Lorenzo Newman | Stress Fracture in the Leg | Out | 8 Weeks |
| Blake Malone | Broken Arm | Out | 5 Weeks |
| Wesley Lane | High Ankle Sprain | Out | 4 Weeks |
| Robert Hulten | Sprained Lateral Knee Ligament | Probable | 3 Weeks |
| Roberto Mitchell | Sprained Knee | Questionable | 3 Weeks |
| Rod Young | Broken Arm | Doubtful | 3 Weeks |
| Bert Marsolais | Sprained Knee | Questionable | 3 Weeks |
| Erick Stamm | High Ankle Sprain | Probable | 2 Weeks |
| Deron Castaneda | Sprained Ankle | Probable | 2 Weeks |
| Ian Brian | Concussion | Out (in concussion protocol) | 1 Week |
| David Kieffer | None | 100% |
|
| Dallas Cowboys | Injury | Status | Expected Return |
| Vernon Carlson | Strained Hamstring | Questionable | Unknown |
| Erick Humes | ACL Knee Surgery | Out | 48 Weeks |
| Marc Davidson | Sprained Lateral Knee Ligament | Probable | 4 Weeks |
| Philip Jacobs | Broken Ribs | Doubtful | 3 Weeks |
| Theodore Huerta | Strained Rotator Cuff | Probable | 2 Weeks |
| Clayton Sweeney | Knee Tendinitis | Probable | 1 Week |
| Thurman McKay | Bad Cold | Probable | 1 Week |
| Riley Bernstein | None | 100% |
|
| Denver Broncos | Injury | Status | Expected Return |
| Andrew Carlisle | Severe Depression | Out | Unknown |
| Nate Granados | Severe Hamstring Pull | Out | 11 Weeks |
| Gustavo Wonders | Broken Foot | Out | 7 Weeks |
| Terrance Jasso | Sprained Lateral Knee Ligament | Probable | 4 Weeks |
| Kaden Summerfield | Bruised Sternum | Probable | 4 Weeks |
| Steve Collier | Hyperextended Elbow | Out | 3 Weeks |
| Gus Kelly | Strained Back | Out | 3 Weeks |
| Ethan Huston | Concussion | Out (in concussion protocol) | 2 Weeks |
| Rickey Solley | Broken Thumb | Probable | 2 Weeks |
| Camden Hanson | Bruised Shoulder | Probable | 1 Week |
| Rusty Godlewski | Bruised Ribcage | Probable | 1 Week |
| Trent Stephenson | Bruised Shoulder | Probable | 1 Week |
| Micah McGinty | None | 100% |
|
| Detroit Lions | Injury | Status | Expected Return |
| Shannon Ottis | ACL Damage to the Knee | Out | 14 Weeks |
| Broderick Bates | Strained Adductor Muscle | Out | 6 Weeks |
| Kirk Bunning | Strained Patellar Tendon | Out | 4 Weeks |
| Hugh Lane | Hyperextended Knee | Out | 4 Weeks |
| Sammy Alcott | Hyperextended Elbow | Out | 4 Weeks |
| Ernie Lemus | Sprained Knee | Questionable | 3 Weeks |
| Irv King | Sprained Ankle | Probable | 1 Week |
| Britt Stargell | Strained Quadriceps Muscle | Probable | 1 Week |
| Louis Rasmussen | Viral Infection | Probable | 1 Week |
| Roy Wolf | None | 100% |
|
| Green Bay Packers | Injury | Status | Expected Return |
| Russell Jordan | MCL Knee Surgery | Out | 22 Weeks |
| Mitchell Baskerville | Severe Hamstring Pull | Questionable | 5 Weeks |
| Byron Schulz | Concussion | Out (in concussion protocol) | 2 Weeks |
| Kris Hamilton | Sprained Ankle | Probable | 1 Week |
| Greg Donaldson | None | 100% |
|
| Ross Wagner | None | 100% |
|
| Darien Yates | None | 100% |
|
| Hayden Conley | None | 100% |
|
| Houston Texans | Injury | Status | Expected Return |
| Jacob Pfaff | Broken Toe | Probable | 2 Weeks |
| Irv Detsch | Broken Finger | Probable | 2 Weeks |
| Dean Cochrane | Strained Elbow Tendon | Probable | 1 Week |
| Chester Gaines | None | 100% |
|
| Eddie Berner | None | 100% |
|
| Indianapolis Colts | Injury | Status | Expected Return |
| Kody Freeman | Turf Toe | Doubtful | Unknown |
| J.R. Binkow | Ruptured Elbow Tendon | Out | 46 Weeks |
| Rob Kubus | Knee Tendinitis | Probable | 4 Weeks |
| Ted Perry | Broken Finger | Probable | 2 Weeks |
| Jon Collins | None | 100% |
|
| Kendrick Malone | None | 100% |
|
| Paul Idonije | None | 100% |
|
| Harris Richmond | None | 100% |
|
| Jacksonville Jaguars | Injury | Status | Expected Return |
| Earnest Shea | Turf Toe | Doubtful | Unknown |
| Emmanuel Frederick | High Ankle Sprain | Out | 16 Weeks |
| Marco Chapman | Broken Foot | Out | 8 Weeks |
| Sean Foley | Sprained Knee | Questionable | 2 Weeks |
| Alejandro Kulaga | Strained Triceps Muscle | Questionable | 2 Weeks |
| Frederick Skrepenak | Broken Arm | Probable | 1 Week |
| Raymond Houston | Elbow Contusion | Probable | 1 Week |
| Mitchell Fitzgerald | None | 100% |
|
| Richard Henning | None | 100% |
|
| Butch Haney | None | 100% |
|
| Tucker Spencer | None | 100% |
|
| Kansas City Chiefs | Injury | Status | Expected Return |
| Gregory Eppright | Strained Hamstring | Questionable | Unknown |
| Josiah Bush | ACL Knee Surgery | Out | 31 Weeks |
| Geoff Gray | Pulled Calf Muscle | Out | 3 Weeks |
| Danny Rose | Broken Toe | Probable | 2 Weeks |
| Los Angeles Rams | Injury | Status | Expected Return |
| Shaun Brooks | Separated Shoulder | Out | 4 Weeks |
| Warren Dulles | Pulled Calf Muscle | Probable | 1 Week |
| Gabe Herron | Pulled Calf Muscle | Questionable | 1 Week |
| Wally McCormick | None | 100% |
|
| Miami Dolphins | Injury | Status | Expected Return |
| J.R. Talley | Torn Ankle Ligament | Out | 22 Weeks |
| Colton Velasco | Dislocated Elbow | Questionable | 2 Weeks |
| Adrian Barrett | Broken Toe | Probable | 2 Weeks |
| Lamont Apel | Strained Deltoid Muscle | Probable | 1 Week |
| Dustin Gonzalez | None | 100% |
|
| Mitchell Sprincz | None | 100% |
|
| Malik Frederick | None | 100% |
|
| Louis Ciccant | None | 100% |
|
| Minnesota Vikings | Injury | Status | Expected Return |
| Robert Rodgers | Broken Toe | Questionable | 3 Weeks |
| Phil Sell | Sprained Thumb | Probable | 3 Weeks |
| Brody Sewell | Strained Deltoid Muscle | Probable | 2 Weeks |
| New England Patriots | Injury | Status | Expected Return |
| Dan O'Donnell | ACL Damage to the Knee | Out | 18 Weeks |
| Dexter Alexander | Torn Rotator Cuff | Out | 12 Weeks |
| Kai Burroughs | Back Surgery | Out | 11 Weeks |
| Joey Stuvaints | Sprained Neck | Probable | 3 Weeks |
| Jeffrey Sutter | Sprained Knee | Questionable | 2 Weeks |
| Bo Brothers | Sprained Neck | Probable | 2 Weeks |
| Brendan Lindsay | Bruised Ribcage | Probable | 1 Week |
| Norm Giles | None | 100% |
|
| Ellis Roberts | None | 100% |
|
| Moe Simonson | None | 100% |
|
| New Jersey Jets | Injury | Status | Expected Return |
| Jamal Ramsey | Turf Toe | Doubtful | Unknown |
| Jon Burks | Pulled Calf Muscle | Out | 5 Weeks |
| Corey Seward | Bad Cold | Probable | 1 Week |
| New Orleans Saints | Injury | Status | Expected Return |
| Sammy Carswell | Torn Wrist Tendon | Out | 6 Weeks |
| Theodore Maese | Torn Knee Cartilage | Out | 3 Weeks |
| Troy Bruner | Broken Wrist | Questionable | 3 Weeks |
| Gene Godfrey | Sprained Ankle | Probable | 2 Weeks |
| William Kemp | Bruised Sternum | Probable | 1 Week |
| Devon Davidson | Separated Shoulder | Probable | 1 Week |
| Josh Hodges | Bruised Ribcage | Probable | 1 Week |
| Marquis Sweeney | None | 100% |
|
| Damien Welker | None | 100% |
|
| New York Giants | Injury | Status | Expected Return |
| Corbin Lowe | Stress Fracture in the Foot | Questionable | 1 Week |
| Pat Beckett | None | 100% |
|
| Cris Farley | None | 100% |
|
| Jason McSwain | None | 100% |
|
| Darrin Atchison | None | 100% |
|
| Oakland Raiders | Injury | Status | Expected Return |
| Fred Sims | Turf Toe | Doubtful | Unknown |
| Drake Kudlacz | Repetitive Concussion Syndrome | Out | 94 Weeks |
| Leonard Irwin | Broken Foot | Doubtful | 5 Weeks |
| Antoine Conley | Shin Splints | Probable | 3 Weeks |
| Heath Somogyi | Broken Arm | Out | 3 Weeks |
| Clyde Whitmire | Sprained Knee | Questionable | 2 Weeks |
| Conner Adams | Torn Knee Cartilage | Questionable | 2 Weeks |
| Christian Sipes | Strained Rotator Cuff | Probable | 1 Week |
| Chance Glover | Strained Quadriceps Muscle | Probable | 1 Week |
| Henry Hockman | Bruised Ribcage | Probable | 1 Week |
| Philadelphia Eagles | Injury | Status | Expected Return |
| Phillip Fayo | Concussion | Out (in concussion protocol) | 4 Weeks |
| Thurman Gryboski | Concussion | Out (in concussion protocol) | 2 Weeks |
| Rodolfo Fields | Sprained Thumb | Probable | 1 Week |
| Riley Wells | Sprained Ankle | Probable | 1 Week |
| Todd Hernandez | Bruised Shoulder | Probable | 1 Week |
| DeAndre Martin | Pulled Groin | Questionable | 1 Week |
| Carlos Grier | Strained Foot Ligament | Probable | 1 Week |
| Pittsburgh Steelers | Injury | Status | Expected Return |
| Cedric Robbins | Strained Elbow Tendon | Out | 4 Weeks |
| J.T. Steuart | Deep Thigh Bruise | Probable | 1 Week |
| Hector Clements | Broken Toe | Probable | 1 Week |
| San Diego Chargers | Injury | Status | Expected Return |
| David Logan | Severe Depression | Out | Unknown |
| Jermaine Bush | Ruptured Elbow Tendon | Out | 38 Weeks |
| Asher Perez | Compound Leg Fracture | Out | 32 Weeks |
| Roberto Gamble | MCL Damage to the Knee | Out | 9 Weeks |
| Courtney Lluellyn | Sprained Knee | Questionable | 4 Weeks |
| Nicholas Van Pelt | Broken Foot | Probable | 3 Weeks |
| Seth Sisco | Sprained Knee | Probable | 1 Week |
| Howard Shipp | None | 100% |
|
| Gino Amos | None | 100% |
|
| Bradley Hill | None | 100% |
|
| San Francisco 49ers | Injury | Status | Expected Return |
| Avery Schindler | Turf Toe | Doubtful | Unknown |
| Billy Gill | ACL Knee Surgery | Out | 11 Weeks |
| Carlton Chapman | Concussion | Out (in concussion protocol) | 4 Weeks |
| Devonte Woods | Knee Tendinitis | Questionable | 3 Weeks |
| Calvin Alston | None | 100% |
|
| Seattle Seahawks | Injury | Status | Expected Return |
| Neil Durham | Turf Toe | Doubtful | Unknown |
| Marco Manning | Torn Lateral Knee Ligament | Out | 11 Weeks |
| B.J. Brookes | Stress Fracture in the Leg | Out | 6 Weeks |
| Cesar O'Neal | Hyperextended Knee | Out | 3 Weeks |
| Jeremy Nixon | Sprained Ankle | Probable | 2 Weeks |
| Bruce Akroyd | Sprained Neck | Probable | 1 Week |
| Lemuel Cassidy | None | 100% |
|
| Mickey Compton | None | 100% |
|
| Kyle Whittenburg | None | 100% |
|
| Ethan Ashcraft | None | 100% |
|
| Rex Sebek | None | 100% |
|
| Wade Carmack | None | 100% |
|
| Ivan Scribner | None | 100% |
|
| Avery Wiley | None | 100% |
|
| Tampa Bay Buccaneers | Injury | Status | Expected Return |
| Micah Paige | ACL Damage to the Knee | Out | 22 Weeks |
| Pedro Chisholm | Strained Foot Ligament | Out | 2 Weeks |
| Archie Kolodzik | Sprained Knee | Probable | 1 Week |
| Luke Woodard | None | 100% |
|
| Tennessee Titans | Injury | Status | Expected Return |
| Irving Tucker | Torn Rotator Cuff | Doubtful | 5 Weeks |
| Herb Butkiewicz | Sprained Neck | Probable | 2 Weeks |
| Ike Lyle | Hip Pointer | Probable | 1 Week |
| Ronnie Houari | Concussion | Out (in concussion protocol) | 1 Week |
| Washington Commanders | Injury | Status | Expected Return |
| Eli Randle | Bruised Sternum | Probable | 4 Weeks |
| Everett Spradlin | Shoulder Tendinitis | Probable | 4 Weeks |
| Gene Mesaros | Pulled Groin | Probable | 1 Week |
| Teddy Dilger | None | 100% |
|
| Clay Pass | None | 100% |
|
| Brody Forbes | None | 100% |
|
| Jamal Writer | None | 100% |
|