| Arizona Cardinals | Injury | Status | Expected Return |
| Derek Johnston | ACL Damage to the Knee | Out | 12 Weeks |
| Abel Phillips | Broken Clavicle | Out | 3 Weeks |
| Harris Newton | Strained Foot Ligament | Out | 2 Weeks |
| Vincent Winters | Sprained Ankle | Probable | 2 Weeks |
| Adrian Leat | Deep Thigh Bruise | Probable | 1 Week |
| Norm Kennedy | Knee Tendinitis | Probable | 1 Week |
| Atlanta Falcons | Injury | Status | Expected Return |
| Miles Desmond | Strained Hamstring | Questionable | Unknown |
| Bennett Hammons | Hyperextended Knee | Out | 4 Weeks |
| Ernie Lyle | None | 100% |
|
| Chandler Yang | None | 100% |
|
| Grant Washington | None | 100% |
|
| Billy Humphries | None | 100% |
|
| Baltimore Ravens | Injury | Status | Expected Return |
| Nicolas Idomir | Strained Hamstring | Questionable | Unknown |
| Britt Legins | Severe Hamstring Pull | Out | 13 Weeks |
| Dylan Dowd | Pulled Groin | Doubtful | 4 Weeks |
| Wendell Shepherd | Hyperextended Knee | Out | 4 Weeks |
| Broderick Kerr | Separated Shoulder | Out | 4 Weeks |
| Rickey Chatham | Sprained Knee | Questionable | 2 Weeks |
| Stan Rydzak | Bruised Ribcage | Probable | 1 Week |
| Gilbert Sheasley | Broken Thumb | Probable | 1 Week |
| Mitchell Berry | Bruised Sternum | Probable | 1 Week |
| Vernon Becker | None | 100% |
|
| Buffalo Bills | Injury | Status | Expected Return |
| Ramon Ripken | Concussion | Out (in concussion protocol) | 10 Weeks |
| Robbie Dillon | None | 100% |
|
| J.J. Marsh | None | 100% |
|
| Carolina Panthers | Injury | Status | Expected Return |
| Wesley Wiggins | Severe Hamstring Pull | Out | 8 Weeks |
| Sammie Coles | Torn Knee Cartilage | Doubtful | 3 Weeks |
| Malik Perry | Sprained Knee | Probable | 2 Weeks |
| Johnny Steen | Strained Calf Muscle | Probable | 2 Weeks |
| Adam Weber | Concussion | Out (in concussion protocol) | 1 Week |
| Willie Donald | Broken Foot | Probable | 1 Week |
| Devante Schwake | None | 100% |
|
| Theodore Lynn | None | 100% |
|
| Roderick Hodges | None | 100% |
|
| Moe Siglar | None | 100% |
|
| Charlie McBrayer | None | 100% |
|
| Chicago Bears | Injury | Status | Expected Return |
| Cameron Nichols | Torn Thumb Ligament | Probable | 2 Weeks |
| Jimmy Nordland | Concussion | Out (in concussion protocol) | 1 Week |
| Cody Woods | None | 100% |
|
| Cincinnati Bengals | Injury | Status | Expected Return |
| Martin Curtis | Strained Patellar Tendon | Doubtful | 4 Weeks |
| Andre Kiel | Strained Foot Ligament | Out | 3 Weeks |
| Claude Polasek | Pulled Groin | Questionable | 2 Weeks |
| Rod Bachofen | Elbow Bursitis | Probable | 2 Weeks |
| Casey McDaniel | Hyperextended Knee | Doubtful | 2 Weeks |
| Lance Horton | Sprained Knee | Questionable | 2 Weeks |
| Darren Carey | Concussion | Out (in concussion protocol) | 1 Week |
| Devante Villareal | Bruised Heel | Probable | 1 Week |
| Darryl Gurley | Broken Nose | Probable | 1 Week |
| Fernando Meadows | None | 100% |
|
| Elliot Thomason | None | 100% |
|
| Cleveland Browns | Injury | Status | Expected Return |
| Roberto Mitchell | ACL Damage to the Knee | Out | 13 Weeks |
| Benjamin Eickholt | ACL Knee Surgery | Out | 8 Weeks |
| Lorenzo Newman | Dislocated Shoulder | Doubtful | 3 Weeks |
| K.C. Davis | Strained Elbow Tendon | Probable | 3 Weeks |
| Randal Woodson | Strained Foot Ligament | Out | 2 Weeks |
| Nathan Walton | Abdominal Strain | Questionable | 2 Weeks |
| Brent Cook | Sprained Thumb | Probable | 1 Week |
| Ronald Avdic | None | 100% |
|
| Dallas Cowboys | Injury | Status | Expected Return |
| Vernon Carlson | Hyperextended Elbow | Questionable | 2 Weeks |
| Brandon Dodge | Concussion | Out (in concussion protocol) | 2 Weeks |
| Denver Broncos | Injury | Status | Expected Return |
| Rusty Godlewski | Compound Leg Fracture | Out | 27 Weeks |
| Francisco Curtis | Broken Fibula | Out | 6 Weeks |
| Douglas Carlisle | Separated Shoulder | Out | 3 Weeks |
| Garrett Michaud | Knee Tendinitis | Probable | 3 Weeks |
| Rickey Solley | None | 100% |
|
| Nolan Lester | None | 100% |
|
| Terrance Jasso | None | 100% |
|
| Kenneth Justice | None | 100% |
|
| Henry Zellner | None | 100% |
|
| Detroit Lions | Injury | Status | Expected Return |
| Richard Clark | Back Surgery | Out | 12 Weeks |
| Christian Kemp | Strained Achilles Tendon | Out | 3 Weeks |
| Anthony Connell | Hyperextended Knee | Doubtful | 2 Weeks |
| Conner Williford | None | 100% |
|
| Green Bay Packers | Injury | Status | Expected Return |
| Hayden Conley | Repetitive Concussion Syndrome | Out | 106 Weeks |
| Terry Dahlin | Shoulder Tendinitis | Probable | 4 Weeks |
| Austin Parker | Bruised Ribcage | Probable | 2 Weeks |
| Josiah Meggett | Sprained Knee | Questionable | 2 Weeks |
| Seth Manculich | Hyperextended Elbow | Doubtful | 2 Weeks |
| Marcus Crawford | Broken Clavicle | Probable | 1 Week |
| Marvin Giancursio | None | 100% |
|
| Houston Texans | Injury | Status | Expected Return |
| Chandler Pratt | Back Surgery | Out | 16 Weeks |
| Chance Bennett | Hyperextended Knee | Questionable | 2 Weeks |
| Dominique Sharber | Concussion | Out (in concussion protocol) | 1 Week |
| Eddie Berner | None | 100% |
|
| Indianapolis Colts | Injury | Status | Expected Return |
| Rusty Schreiner | Strained Hamstring | Questionable | Unknown |
| Wade Barber | Turf Toe | Doubtful | Unknown |
| J.R. Binkow | Ruptured Elbow Tendon | Out | 37 Weeks |
| Victor Godfrey | Torn Ankle Ligament | Out | 16 Weeks |
| Alejandro Gomez | Torn Wrist Tendon | Out | 9 Weeks |
| Marvin Robbins | Sprained Lateral Knee Ligament | Probable | 4 Weeks |
| Abraham Bosela | Knee Tendinitis | Probable | 2 Weeks |
| Dean Vilimek | Deep Thigh Bruise | Probable | 2 Weeks |
| Jacksonville Jaguars | Injury | Status | Expected Return |
| Emmanuel Frederick | Broken Foot | Out | 6 Weeks |
| Mickey Compton | Dislocated Elbow | Out | 5 Weeks |
| Sean Foley | Strained Elbow Tendon | Out | 3 Weeks |
| Arturo Joseph | Hyperextended Knee | Probable | 1 Week |
| Tracy Bedwell | Broken Ankle | Probable | 1 Week |
| Miles Lynn | Hyperextended Elbow | Probable | 1 Week |
| Brody Hickman | None | 100% |
|
| Mitchell Fitzgerald | None | 100% |
|
| Tyrell Fabini | None | 100% |
|
| Kansas City Chiefs | Injury | Status | Expected Return |
| Jonathan Hartman | Hyperextended Elbow | Questionable | 2 Weeks |
| Francisco Johnson | Viral Infection | Probable | 1 Week |
| Kelvin Rodgers | None | 100% |
|
| Ronald Westbrook | None | 100% |
|
| Los Angeles Rams | Injury | Status | Expected Return |
| Vinny Jacquet | Inguinal Hernia | Out | 20 Weeks |
| Adrian Warren | Broken Nose | Probable | 2 Weeks |
| Douglas Garrison | Torn Calf Muscle | Questionable | 2 Weeks |
| Larry Tyler | Torn Knee Cartilage | Doubtful | 2 Weeks |
| Henry Tucker | Strained Quadriceps Muscle | Probable | 2 Weeks |
| Quentin Gaulin | Strained Triceps Muscle | Probable | 1 Week |
| Michael Turnbull | None | 100% |
|
| Wesley Ramirez | None | 100% |
|
| Jeffery Ellison | None | 100% |
|
| Miami Dolphins | Injury | Status | Expected Return |
| Devon Gallardo | Broken Clavicle | Out | 7 Weeks |
| Leon Bandhauer | Pulled Groin | Questionable | 2 Weeks |
| Amari Lindsay | Knee Contusion | Probable | 1 Week |
| Minnesota Vikings | Injury | Status | Expected Return |
| Mario Horton | ACL Damage to the Knee | Out | 17 Weeks |
| Ronnie Doss | Broken Arm | Doubtful | 3 Weeks |
| Darrell Lekin | Strained Foot Ligament | Out | 3 Weeks |
| Efrain Samuels | Hyperextended Elbow | Out | 3 Weeks |
| Lincoln Tyree | Concussion | Out (in concussion protocol) | 1 Week |
| Randal Fritz | None | 100% |
|
| Ty Martinez | None | 100% |
|
| Colin Briggs | None | 100% |
|
| New England Patriots | Injury | Status | Expected Return |
| Axel Melino | ACL Knee Surgery | Out | 45 Weeks |
| Pete Barnes | Severe Hamstring Pull | Out | 18 Weeks |
| J.R. Issa | Sprained Lateral Knee Ligament | Questionable | 8 Weeks |
| Joe Hostetler | Hyperextended Elbow | Questionable | 2 Weeks |
| Duane Darusmont | Knee Tendinitis | Probable | 2 Weeks |
| Alfred Castroll | None | 100% |
|
| Corbin Asher | None | 100% |
|
| New Jersey Jets | Injury | Status | Expected Return |
| Robbie Maloney | Strained Hamstring | Questionable | Unknown |
| Rodolfo Hardy | Concussion | Out (in concussion protocol) | 4 Weeks |
| Cooper Coles | Sprained Knee | Probable | 2 Weeks |
| Theodore Chisolm | Hyperextended Elbow | Probable | 1 Week |
| Claude Dreiser | Pulled Groin | Probable | 1 Week |
| Wes Leisure | None | 100% |
|
| Arturo Hoffman | None | 100% |
|
| Drew Caniglia | None | 100% |
|
| New Orleans Saints | Injury | Status | Expected Return |
| Marcos Quinn | Ankle Surgery | Out | 20 Weeks |
| Bryson Tucker | Strained Rotator Cuff | Probable | 2 Weeks |
| Kelly Hawkins | Sprained Thumb | Probable | 1 Week |
| Brock Bernard | None | 100% |
|
| Ivan Arnold | None | 100% |
|
| New York Giants | Injury | Status | Expected Return |
| K.C. Renteria | ACL Damage to the Knee | Out | 24 Weeks |
| Ezra Fisher | Torn Rotator Cuff | Out | 11 Weeks |
| Devonte Tank | Broken Foot | Out | 10 Weeks |
| Rod Guthrie | Concussion | Out (in concussion protocol) | 4 Weeks |
| Bill Preston | Knee Tendinitis | Probable | 3 Weeks |
| Troy Garcia | Sprained Lateral Knee Ligament | Probable | 2 Weeks |
| Mason Pelshak | Strained Calf Muscle | Probable | 2 Weeks |
| Kenyon Rice | Broken Nose | Probable | 1 Week |
| Oakland Raiders | Injury | Status | Expected Return |
| Cesar Cote | Strained Hamstring | Questionable | Unknown |
| Sergio Einertson | Compound Leg Fracture | Out | 40 Weeks |
| Ricardo Hempstead | ACL Knee Surgery | Out | 31 Weeks |
| Fred Sims | Broken Toe | Probable | 2 Weeks |
| Cody Bellis | Strained Foot Ligament | Probable | 1 Week |
| Hardy Gil | Sprained Ankle | Probable | 1 Week |
| Alejandro Burroughs | None | 100% |
|
| Van Horner | None | 100% |
|
| Philadelphia Eagles | Injury | Status | Expected Return |
| Jon Meadows | Compound Leg Fracture | Out | 29 Weeks |
| DeAndre Martin | Sprained Ankle | Probable | 2 Weeks |
| Myles Sutter | None | 100% |
|
| Pittsburgh Steelers | Injury | Status | Expected Return |
| Joey Robbins | Concussion | Out (in concussion protocol) | 5 Weeks |
| Sammy Tanner | Sprained Knee | Questionable | 3 Weeks |
| Jeffery Shea | Sprained Knee | Questionable | 2 Weeks |
| Lenny Hooper | Separated Shoulder | Out | 2 Weeks |
| Alexander Linquist | Concussion | Out (in concussion protocol) | 1 Week |
| San Diego Chargers | Injury | Status | Expected Return |
| Darren Fields | Torn Ankle Ligament | Out | 16 Weeks |
| Bradley Hill | Bruised Sternum | Probable | 4 Weeks |
| Corbin Palmer | Strained Rotator Cuff | Probable | 2 Weeks |
| Ben Clayton | Sprained Thumb | Probable | 2 Weeks |
| Jeffrey Winkler | Separated Shoulder | Questionable | 2 Weeks |
| Francisco Kornegay | Hyperextended Elbow | Doubtful | 2 Weeks |
| Abel Jarvis | Broken Finger | Probable | 1 Week |
| Norbert Sylvester | None | 100% |
|
| Frederick Salas | None | 100% |
|
| San Francisco 49ers | Injury | Status | Expected Return |
| Alfred Jenkins | Degenerative Hip Condition | Out | 36 Weeks |
| Eric Powell | Torn Lateral Knee Ligament | Out | 14 Weeks |
| Kendrick Webster | Broken Arm | Out | 5 Weeks |
| Lance Whitt | Broken Tibia | Out | 4 Weeks |
| Harry Phillips | Strained Achilles Tendon | Out | 3 Weeks |
| Christian Harper | Concussion | Out (in concussion protocol) | 3 Weeks |
| Hunter Ozols | Broken Foot | Probable | 1 Week |
| Silas Leinaweaver | None | 100% |
|
| Carlton Chapman | None | 100% |
|
| Seattle Seahawks | Injury | Status | Expected Return |
| Philip Jacobs | ACL Knee Surgery | Out | 14 Weeks |
| Ashton McCormick | Separated Shoulder | Out | 6 Weeks |
| Ashton Reese | Separated Shoulder | Out | 4 Weeks |
| Brady Hancock | Hyperextended Knee | Out | 4 Weeks |
| Martin Lambuth | None | 100% |
|
| Jared Delgado | None | 100% |
|
| Tampa Bay Buccaneers | Injury | Status | Expected Return |
| Harris Goings | Degenerative Hip Condition | Out | 67 Weeks |
| Mel Santana | Broken Finger | Probable | 3 Weeks |
| Daniel Weber | Knee Tendinitis | Probable | 3 Weeks |
| Deion Owens | Bruised Ribcage | Probable | 2 Weeks |
| Todd Shepherd | Knee Bursitis | Probable | 2 Weeks |
| Abel Dunphy | None | 100% |
|
| Tyrone Kemp | None | 100% |
|
| Zach McSherry | None | 100% |
|
| Tennessee Titans | Injury | Status | Expected Return |
| Wayne Lunderville | Repetitive Concussion Syndrome | Out | 124 Weeks |
| Ronnie Houari | Bruised Ribcage | Probable | 2 Weeks |
| Lukas Watson | Broken Finger | Probable | 1 Week |
| Jorge Palmer | Pulled Groin | Probable | 1 Week |
| Ernie Hatton | None | 100% |
|
| Nathaniel Dobler | None | 100% |
|
| Washington Commanders | Injury | Status | Expected Return |
| Dan Warren | Severe Wrist Sprain | Out | 5 Weeks |
| Winston Lane | Sprained Knee | Questionable | 3 Weeks |
| Tyrell Middleton | Knee Bursitis | Probable | 1 Week |
| Clay Pass | Separated Shoulder | Probable | 1 Week |
| Harry de la Rosa | Broken Finger | Probable | 1 Week |
| Wayne Sampson | None | 100% |
|